Data Resources

Open data resources accelerate scientific progress. We prioritize reproducible methods, minimal access requirements, and releasing fully-processed data.

In order to better understand mental illnesses as disorders of brain development, Reproducible Brain Charts (RBC; N = 6,346) aggregates several of the largest studies of brain development in youth as a publicly available data resource for the scientific community.

Key measures: sMRI, fMRI, psychiatric phenotyping

# downloads: >6,000 (as of 4/1/2026)

Shafiei, G. et al., An open data resource for mapping brain development and its associations with mental health. Neuron. 2025; 113, 3758-3779.e6; doi: https://doi.org/10.1016/j.neuron.2025.08.026

Synthesis of Psychedelic Research Studies (SYPRES) is an open-data living systematic review and meta-analytic resource that synthesizes evidence from randomized controlled trials of psychedelic-assisted therapies. SYPRES currently includes databases for psilocybin for depression (N = 801 across 15 studies) and MDMA for PTSD (N = 286 across 6 studies), with additional reviews on-going.

Key resources: open effect size databases, reproducible analysis code, interactive dashboards

# downloads: > 80 (as of 4/1/2026)

Singleton, S.P. et al., An initiative for living evidence synthesis in clinical psychedelic research. Nature Mental Health. 2025;3(1):3-5. doi: https://doi.org/10.1038/s44220-024-00373-4

The Penn Affective Instability Study (PAFIN; N = 49) includes detailed measures of sleep, mood variability, and brain development

Key measures: ME-fMRI, CS-DSI, ASL, EMA, actigraphy, cognitive assessments, self-report scales

Brook, J.B.H., Salo, T. et al., An open, fully-processed data resource for studying mood and sleep variability in the developing brain. Aperture Neuro. 2026. (in press); doi: https://doi.org/10.52294/001c.151820

In order to promote transdiagnostic research on executive function during development, the Penn Longitudinal Executive functioning in Adolescent Development study (Penn LEAD; N = 132) combines longitudinal multi-modal imaging data with rich clinical and cognitive phenotyping.

Key measures: sMRI, task fMRI, dMRI, ASL, resting-state fMRI, cognitive assessments, self-report scales

Sevchik, B.L., et al., An open, fully-processed, longitudinal data resource to study brain development and transdiagnostic executive function. bioRxiv. 2025; doi: https://doi.org/10.1101/2025.11.10.687633