Data Resources

Open data resources accelerate scientific progress. We prioritize reproducible methods, minimal access requirements, and releasing fully-processed data.

In order to better understand mental illnesses as disorders of brain development, Reproducible Brain Charts (RBC; N = 6,346) aggregates several of the largest studies of brain development in youth as a publicly available data resource for the scientific community.

Key measures: sMRI, fMRI, psychiatric phenotyping

# downloads: >6,000

Shafiei G, Esper NB, Hoffmann MS, Ai L, Chen AA, Cluce J, Covitz S, Giavasis S, Lane C, Mehta K, Moore TM, Salo T, Tapera TM, Calkins ME, Colcombe S, Davatzikos C, Gur RE, Gur RC, Pan PM, Jackowski AP, Rokem A, Rohde LA, Shinohara RT, Tottenham N, Zuo XN, Cieslak M, Franco AR, Kiar G, Salum GA, Milham MP, Satterthwaite TD. Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health. Neuron. 2025; 113, 3758-3779.e6; doi: https://doi.org/10.1016/j.neuron.2025.08.026

The Penn Affective Instability Study (PAFIN; N = 49), an open data resource of densely phenotyped behavioral and imaging data, serves to identify meaningful links between sleep, mood, and brain development.

Key measures: ME-fMRI, CS-DSI, ASL, EMA, actigraphy, cognitive assessments, self-report scales

Brook JBH, Salo T, Luo AC, Bagautdinova J, Rush S, Alexander-Bloch AF, Baller EB, Calkins ME, Cieslak M, Cooper EC, Detre JA, Elliott MA, Fair DA, Freedman P, Gehrman PR, Gur RC, Gur RE, Klein A, Laney N, Laumann TO, Mehta K, Merikangas KR, Milham MP, Mitchell JA, Moore TM, Nelson SM, Ruparel K, Sevchik BL, Shanmugan S, Shou H, Taso M, White LK, Wolf DH, Tisdall MD, Roalf DR, Satterthwaite TD. An open, fully-processed data resource for studying mood and sleep variability in the developing brain. Aperture Neuro. 2026. (in press); doi: https://doi.org/10.52294/001c.151820

In order to promote transdiagnostic research on executive function during development, the Penn Longitudinal Executive functioning in Adolescent Development study (Penn LEAD; N = 132) combines longitudinal multi-modal imaging data with rich clinical and cognitive phenotyping.

Key measures: sMRI, task fMRI, dMRI, ASL, resting-state fMRI, cognitive assessments, self-report scales

Sevchik BL, Shafiei G, Murtha K, Linguiti S, Brodrick L, Brook JBH, Cieslak M, Flook E, Mehta K, Meisler SL, Ruparel K, Rush S, Salo T, Singleton SP, Tong TT, Salunke M, Bassett DS, Calkins ME, Elliott MA, Gur RE, Gur RC, Moore TM, Scott JC, Shinohara RT, Tisdall MD, Wolf DH, Roalf DR, Satterthwaite TD. An open, fully-processed, longitudinal data resource to study brain development and transdiagnostic executive function. bioRxiv. 2025; doi: https://doi.org/10.1101/2025.11.10.687633

Synthesis of Psychedelic Research Studies (SYPRES) is an open-data living systematic review and meta-analytic resource that synthesizes evidence from randomized controlled trials of psychedelic-assisted therapies. SYPRES currently includes databases for psilocybin for depression (N = 801 across 15 studies) and MDMA for PTSD (N = 286 across 6 studies), with additional reviews on-going.

Key resources: open effect size databases, reproducible analysis code, interactive dashboards

# downloads: > 80

Singleton SP, Sevchik BL, Vandekar SN, Strain EC, Nayak SM, Dworkin RH, Scott JC, Satterthwaite TD. An initiative for living evidence synthesis in clinical psychedelic research. Nature Mental Health. 2025;3(1):3-5. doi: https://doi.org/10.1038/s44220-024-00373-4