Intrinsic timescale is a commonly used measure of spontaneous neural dynamics that quantifies the temporal window of processing in neuronal populations. It displays a hierarchical cortical organization across species and imaging modalities, with shorter timescales in sensorimotor cortex and longer timescales in association cortex. However, less is known about how intrinsic timescale evolves during human brain development. Here, we estimate intrinsic timescale in two independent youth datasets (HCPD: n=565; HBN: n=729; ages 8–22) and examine its developmental patterns. We find that changes in intrinsic timescale follow a hierarchical gradient along the sensorimotor-to-association (S–A) axis. Analysis of an independent adult dataset (HCPYA: n=973; ages 22–37) suggests this pattern stabilizes in adulthood. Together, these findings highlight intrinsic timescale as a marker of hierarchical brain maturation during development.

Here, we present the results of a fully pre-registered, living systematic review on psilocybin treatment for depressive symptoms. The original studies included in our primary meta-analysis suggest promise: compared to control conditions, psilocybin showed a greater reduction in depression scores, greater treatment response, and higher remission rates. Notably, our living review will be regularly updated, with all data, code, and results openly available on our public website for the SYPRES initiative (Synthesis of Psychedelic Research Studies; sypres.io). Our continuously maintained database already includes over 200 total effect sizes, encompassing all depression timepoints and outcomes reported by arm in each of the 15 randomized controlled clinical trials included.

Here, we present the results of a fully pre-registered, living systematic review on MDMA treatment for PTSD symptoms. The original studies included in our primary meta-analysis suggest promise: compared to control conditions, MDMA showed a greater reduction in PTSD scores, greater treatment response, and higher remission rates. Meta-regression on both the number of dosing sessions and cumulative dose showed that a higher number of dosing sessions and a higher cumulative dose was related to larger effects of MDMA. Notably, our living review will be regularly updated, with all data, code, and results openly available on our public website for the SYPRES initiative (Synthesis of Psychedelic Research Studies; sypres.io). Our continuously maintained database already includes over 60 total effect sizes, encompassing all PTSD timepoints and outcomes reported by arm in each of the 6 randomized controlled clinical trials included.