Here, we present the results of a fully pre-registered, living systematic review on psilocybin treatment for depressive symptoms. The original studies included in our primary meta-analysis suggest promise: compared to control conditions, psilocybin showed a greater reduction in depression scores, greater treatment response, and higher remission rates. Notably, our living review will be regularly updated, with all data, code, and results openly available on our public website for the SYPRES initiative (Synthesis of Psychedelic Research Studies; sypres.io). Our continuously maintained database already includes over 200 total effect sizes, encompassing all depression timepoints and outcomes reported by arm in each of the 15 randomized controlled clinical trials included.

Here, we present the results of a fully pre-registered, living systematic review on MDMA treatment for PTSD symptoms. The original studies included in our primary meta-analysis suggest promise: compared to control conditions, MDMA showed a greater reduction in PTSD scores, greater treatment response, and higher remission rates. Meta-regression on both the number of dosing sessions and cumulative dose showed that a higher number of dosing sessions and a higher cumulative dose was related to larger effects of MDMA. Notably, our living review will be regularly updated, with all data, code, and results openly available on our public website for the SYPRES initiative (Synthesis of Psychedelic Research Studies; sypres.io). Our continuously maintained database already includes over 60 total effect sizes, encompassing all PTSD timepoints and outcomes reported by arm in each of the 6 randomized controlled clinical trials included.

Despite decades of neuroimaging research, how white matter develops along the length of major tracts in humans remains unknown. Here, we identify fundamental patterns of white matter maturation by examining developmental variation along major, long-range cortico-cortical tracts in youth ages 5-23 years using diffusion MRI from three large-scale, cross-sectional datasets (total N = 2,710). Across datasets, we delineate two replicable axes of human white matter development. First, we find a deep-to-superficial axis, in which superficial tract regions near the cortical surface exhibit greater age-related change than deep tract regions. Second, we demonstrate that the development of superficial tract regions aligns with the cortical hierarchy defined by the sensorimotor-association axis, with tract ends adjacent to sensorimotor cortices maturing earlier than those adjacent to association cortices.