Molecular Psychiatry

1/25/21

Gluatmate and Reward Responsiveness

We used ultra-high field (7T) glutamate imaging to delineate deficits in reward responsiveness across psychiatric disorders.

Developmental Cognitive Neuroscience

4/18/20

Leveraging multi-shell diffusion for studies of brain development in youth and young adulthood

We find key advantages of multi-shell diffusion metrics, including increased neurodevelopmental coupling and decreased spurious relationships with imaging data quality.

Journal of Neuroscience

2/27/20

Longitudinal Development of Brain Iron

Diminished brain iron accumulation in the basal ganglia is associated with poorer cognitive performance during adolescence.

PNAS

1/2/20

Development of Structure Function Coupling

Coupling between structural and functional brain networks evolves in a hierarchy-dependent manner in youth

Biological Psychiatry

9/18/19

Neurostructural Heterogenity in Mood and Anxiety Disorders

We used a semi-supervised machine learning tool to parse heterogeneity in mood and anxiety disorders in youth

Nature Protocols

11/18/18

Protocol for mitigating motion artifact

We define a structured protocol for the evaluation and mitigation of motion artifact in functional connectivity MRI.

Cerebral Cortex

4/1/18

Prematurity and Structural Brain Development

Prematurity is associated with the deficit in executive function and abnormalities in structural covariance networks.

Journal of Neuroscience

2/18/18

Cortical thickness and adolescent impulsivity

In collaboration with Joe Kable, we demonstrate that impulsive choice during adolescence is associated with reduced cortical thickness in regions critical for reward valuation.

Molecular Psychiatry

9/17/17

Overall psychopathology and cerebral blood flow

Higher levels of overall psychopathology across disorders are associated with differences in cerebral blood flow in key brain regions such as the anterior cingulate cortex.

Current Biology

6/5/17

Development of Structural Brain Networks

Structural brain networks grow more segregated during adolescent development, and support executive functioning.

Biological Psychiatry

11/1/16

Amygala perfusion and anxiety

We demonstrate that normative developmental sex differences in perfusion of brain regions involved in emotion and social cognition -- such as the amygdala-- mediate established sex differences in mood and anxiety symptoms in youth.

Curr Op in Behav Science

4/26/16

Review: Executive function and development

We review recent work investigating the neural basis for executive development during childhood and adolescence.

Neuropsychopharmacology

3/13/15

Common reward deficits in unipolar and bipolar depression

Similar reward system deficits are dimensionally present in both unipolar and bipolar depression.

NeuroImage

2/1/14

Neuroimaging of the Philadelphia Neurodevelopmental Cohort

This provides an overview of the imaging procedures of the PNC, a large-scale NIMH-funded study (PI: Raquel E. Gur).

NeuroImage

3/1/12

Motion and functional connectivity

We provide one of the first descriptions of motion artifact's impact on functional connectivity.

JAMA Network Open

1/5/21

fMRI of Chronic Pain: A Meta Analysis

A comprehensive meta-analysis revealed that chronic pain does not appear to be associated with consistent alterations in the brain’s response to noxious stimuli.

eLife

4/1/20

Control Energy of Executive Function in Youth

We leveraged advances in network control theory to describe how the structural connectome facilitates transitions to executive activation states

Neuron

2/19/20

Personalized Association Networks in Youth

Individual-specific association networks are refined in youth and predict cognition

Biological Psychiatry

12/23/19

Review: Parsing Heterogeneity in Psychopathology

This review provides an overview of methods for defining common and dissociable aspects of psychopathology

Neuropsychopharmacology

9/1/19

Irritability and Longitudinal Brain Development

Irritability is associated with accelerated cortical thinning in youth

Nature Communications

8/1/18

Dimensions of Psychopathology and Functional Brain Network

Machine-learning links dimensions of psychopathology to abnormalities of functional brain networks.

Neuoimage

4/1/18

Quantitative assessment of structural image quality

We assessed quantitative metrics of structural image quality, and described how image quality may impact inference about brain development.

Nature Communications

11/1/17

Network control in brain development

In collaborative work with Danielle Bassett, we show that brain networks become more controllable with development in adolescence.

American Journal of Psychiatry

7/31/17

Reward dysconnectivity in psychiatry

We delineate common functional connectivity abnormalities in the brain's reward system across mood and psychotic disorders.

Human Brain Mapping

5/11/17

Hypergraphs in developing networks

In collaborative work with Danielle Bassett, we uncover novel developmental network features in high-resolution network hypergraphs.

NeuroImage

6/1/16

Cortical coupling

Here we introduce a new measure --cortical coupling-- that describes the local association between brain measures.

American Journal of Psychiatry

1/22/16

Transdiagnostic Executive Dysfunction in Youth

We investigated executive system deficits in association with dimensions of psychiatric symptoms in youth using a working memory paradigm.

Journal of Neuroscience

1/29/15

Cortical topology and development

Here we show that cortical thinning in adolescence is partially governed by sulcal topology.

Journal of Neuroscience

10/13/13

Functional Maturation of the Executive System

Using fMRI and machine learning tools, we demonstrate that executive system activation is more strongly linked to individual differences in performance ability than chronological age.

Neuropsychopharmacology

10/2/20

Neurocognitive and functional heterogeneity in depressed youth

We identified neurocognitive subtypes of depressed youth using semi-supervised machine learning.

Human Brain Mapping

3/26/20

Multi‐scale network regression for brain‐phenotype associations

We designed, implemented, and deployed a multi-variate statistical tool to extract novel brain‐behavior relationships that are present on multiple scales.

Neurosci and Biobehav Rev

1/17/20

Convergent Neural Representation of Pain

Diverse experiments inducing acute pain in healthy volunteers recruit a convergent pattern of activation.

American Journal of Psychiatry

12/1/19

Dimensions of Psychopathology and Brain Structure

Dissociable impact of dimensions of psychopathology on brain structure

Cerebral Cortex

8/23/19

Unifying Modular and Core-Periphery Networks

We a recently-developed stochastic block model that simultaneously uncovers modular and core–periphery structure

NeuroImage

6/1/18

Motion and Diffusion-Based Structural Networks

The impact of in-scanner head motion on structural connectivity derived from diffusion MRI.

Biological Psychiatry: CNNI

3/31/18

Review: Network neuroscience and neuropsychiatric disorders

We aim to offer an accessible introduction to this emerging field and motivate further work that uses NN to better understand the normative development of brain networks and alterations in that development that accompany or foreshadow psychiatric disease.

Human Brain Mapping

11/1/17

Review: Motion and functional connectivity

This review article provides an overview of the way in-scanner motion impacts functional connectivity data, as well as common approaches for mitigating this artifact.

NeuroImage

7/1/17

Benchmarking functional connectivity pipelines

We benchmark 14 of the most commonly used preprocessing pipelines for functional connectivity. This paper was one of the top 3 cited papers in 2017 published in NeuroImage.

PNAS

3/31/17

Developmental cortical networks and evolutionary expansion

In collaborative work with Christos Davatzikos, we define novel structural covariance networks, and show that their development during adolescence is associated with evolutionary expansion.

JAMA Psychiatry

5/1/16

Structural brain abnormalities in psychosis spectrum youth

We document structural brain abnormalities in youth with psychosis-spectrum symptoms, including medial temporal lobe regions such as the hippocampus.

PNAS

11/3/15

Functional network development in adolescence

In collaborative work with Danielle Bassett, we track how the roles of functional sub-networks evolve in adolescence.

PNAS

6/10/14

Sex differences in cerebral blood flow in adolescence

We delineate fundamental normative sex differences in CBF evolution during adolescence.

NeuroImage

1/1/13

Preprocessing for motion artifact

We introduce a top-performing strategy for reducing motion artifact in functional connectivity data.